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Taking care of your Loved One Is What We Do BEST!

It's no secret, most of us would like to stay in our own home as we age. Yet, sometimes our loved ones just need a little extra help to remain comfortable at home. That's where Always Best Care can help....we are dedicated to exceeding expectations....always

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Home Care In South San Francisco, CA

Home Care South San Francisco, CA

They say that your golden years are the best years of your life. For most older Americans, that's how it should be - a time to relax, reflect, and live life in a familiar place. After all, senior citizens in the U.S. have worked tirelessly to build a better economy, serve their communities, and raise families.

However, as seniors grow older, completing daily tasks like showering and enjoying activities such as visiting the historic PlymireSchwarz House Museum gets harder without someone by their side. Unfortunately, many older Americans aren't able to rely on their adult children for help. The reality in today's world is that family members do not have the skills or time to dedicate to caring for their parents. That's where Always Best Care Senior Services comes in.

Our in-home care services are for people who prefer to stay at home as they grow older but need ongoing care that family or friends cannot provide. More and more older adults prefer to live far away from long-term, institutionalized facilities and closer to the place where they feel most comfortable - their home. Home care in South San Francisco, CA is a safe, effective way to give your loved ones the care they need when they need it the most.

 In-Home Care South San Francisco, CA

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The Always Best Care Difference

Since 1996, Always Best Care has provided non-medical in-home care for seniors to help them maintain a healthy lifestyle as they get older. We are proud to have helped more than 25,000 seniors maintain higher levels of dignity and respect. We focus on providing seniors with the highest level of in-home care available so that they may live happily and independently.

Unlike some senior care companies, we genuinely want to be included in our clients' lives. We believe that personalized care is always the better option over a "one size fits all" approach. To make sure our senior clients receive the best care possible, we pair them with compassionate caregivers who understand their unique needs. That way, they may provide care accordingly without compromising their wellbeing.

The Always Best Care difference lies in life's little moments - where compassionate care and trustworthy experience come together to help seniors live a fruitful, healthy life. Whether you are an aging adult that can't quite keep up with life's daily tasks or the child of a senior who needs regular in-home services, Always Best Care is here to help.

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TESTIMONIALS

“This is a great company to work for, everyone is extremely considerate and maintains open communication :)”

Andrea A.
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TESTIMONIALS

“I required 2 months of live-in care after a bone marrow transplant. I was put up at a little apartment near Stanford Hospital. I absolutely loved my caregivers! They had to drive me to appointments, assist with grocery shopping, drive me to pick up prescriptions, etc. Plus do the housework around the apartment. They made a long stay away from my husband, pets and home very pleasant.”

Anita T.
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TESTIMONIALS

“Work with the senior people is wonderful ????????”

TERESA S.
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TESTIMONIALS

“I love to work in Always Best Care they nice”

Anna
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TESTIMONIALS

“One of the best Senior Care Services I’ ve known and joined. The management and staff are really nice, caring, supportive and approachable. You feel like home with them.”

Noel T.
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TESTIMONIALS

“We're very fortunate to have ABC assist us with our caregiving needs. They worked with us to find the right fit of caregivers who can attend to my parents' needs and had the essential cultural background.”

Don T.
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TESTIMONIALS

“Can I give this agency 10 stars? Angela has been wonderful to work with and her staff of caregivers have been professional and responsive. We're still clients and very happy with the care provided.”

Pauline J.
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TESTIMONIALS

“Carrie is wonderful, She always puts 100% effort in everything she does.”

Sjoerd V.
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“Been with them two months and already seeing excellent results. Can't wait to see what the next few months are like.”

Alton A.
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“matt and carrie are seo superstars i highly recommend them. Great experience.”

Mark R.
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“Highly recommend Mr. Marketing SEO. Experts in the marketing space and their team is great to work with.”

Zechariah J.
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“Mr. Marketing SEO team gets the job done. we have seen an enormous increase in sales”

Sunnyvale F.
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“Been with them two months and already seeing great results. can't wait to see what the next few months are like.”

Robin C.
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“Matt and Carrie are seo superstars I highly recommend them.”

Robert N.
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“Carrie's fantastic she always puts 100% effort in everything she does”

Wayne P.
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“Very professional and knowledgeable.”

Timothy J.
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“Cody and Matt are great at what they do. If you need a company to help you with you local SEO these guys are the best.”

Mary J.
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“Thanks for the tips, have a wonderful day”

David R.
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TESTIMONIALS

“I am a past client of this provider Five stars for Always Best Care of Peninsula? No! SIX STARS go to Angela, Ramon, and the gang in the field who make this agency top of the line. What makes it so special is their ability to place just the right skilled worker with the needy client. They all go the extra mile, and that is rare these days. And, finally ... they actually return phone calls!”

Gretchen123
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TESTIMONIALS

“I am a current client of this provider Their customer service was excellent and they were able to find a fantastic caregiver on short notice without having to do a preliminary home study or anything. I needed someone for backup care for my mom for the next day and they were able to oblige. My mom loved the caregiver and I felt the management really cared about my mom as they gave me some information on her condition and some needs she had that were not being met.”

cbaker111
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TESTIMONIALS

“I would highly recommend Always Best Care for your needs with your loved ones. I found the representative Angela extremely knowledgeable, professional, caring, understanding, and patient with my needs. The board and care homes that were shown to me for my uncle are excellent with professional staffing, clean, comfortable, and safe surroundings. Covid precautions were in place for the safety of everyone. I honestly can say I would have felt happy to check into one of the board and care homes myself.”

Ingrid L.
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TESTIMONIALS

“Angela and her team have been helping me with my Dad for the last 4 years. As my Dad's needs have changed ABC has come to my rescue. I started out needing someone to help me for a couple hours. We progressed to a point that my Dad needed 24 hr care. Angela provided around the clock care in my Dad's home until his health stabilized. After his stabilization, Angela helped me find a wonderful Board & Care facility where my Dad has been living for two years. Last year, when I found that I could no longer take my Dad on outings by myself, Angela started sending Mark to accompany us on outings. ABC has been there for us every step of the way. I would not think twice about calling them for help and I would recommend them in an instant.”

Marie P.
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TESTIMONIALS

“Shirley McElhattan is one of the best in this business! She truly cares about the families she helps and goes out of her way to make the transition into a home as easy as possible. ABSOLUTELY AMAZING WORK!!!”

Frank K.
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TESTIMONIALS

“You can not get a better working partner than Angela Encarnacion From Best Care Senior Services. Her professionalism and caring attitude made it so smooth to place a new resident in our RCFE home, both for the family and us. It is such a difficult and challenging situation to transfer an elder to a Board and Care but she was the in between person that just made the move a huge success. I am so impressed how detail oriented, punctual and knowledgeable she is. Her experience just facilitates any transaction because she has already thought of what is needed and its already taken care of before the situation arises. Just fabulous! Can't get Best Care Senior Services than what Angela offers!”

Fabian R.

What is Non-Medical Senior Care in South San Francisco, CA?

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Home is where the heart is. While that saying can sound a tad cliche, it is especially true for many seniors living in America. When given a choice, older adults most often prefer to grow older at home. An AARP study found that three out of four adults over the age of 50 want to stay in their homes and communities as they age.

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When you begin to think about why, it makes sense. Home offers a sense of security, comfort, and familiarity.

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The truth is, as we age, we begin to rely on others for help. When a family is too busy or lives too far away to fulfill this role, in-home senior care is often the best solution. Home care services allow seniors to enjoy personal independence while also receiving trustworthy assistance from a trained caregiver.

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At Always Best Care, we offer a comprehensive range of home care services to help seniors stay healthy while they get the help they need to remain independent. As your senior loved one gets older, giving them the gift of senior care is one of the best ways to show your love, even if you live far away.

 Senior Care South San Francisco, CA

Types of Elderly Care in South San Francisco, CA

To give our senior clients the best care possible, we offer a full spectrum of in-home care services:

Personal Care

Personal Care Services

If your senior loved one has specific care needs, our personal care services are a great choice to consider. Personal care includes the standard caregiving duties associated with companion care and includes help with tasks such as dressing and grooming. Personal care can also help individuals with chronic conditions like diabetes.

Common personal care services include assistance with:

  • Eating
  • Mobility Issues
  • Incontinence
  • Bathing
  • Dressing
  • Grooming

Respite Care South San Francisco, CA
Home Helper

Home Helper Services

Sometimes, seniors need helpful reminders to maintain a high quality of life at home. If you or your senior has trouble with everyday tasks like cooking, our home helper services will be very beneficial.

Common home helper care services include assistance with:

  • Medication Reminders
  • Meal Preparation
  • Pet Care
  • Prescription Refills
  • Morning Wake-Up
  • Walking
  • Reading
 Caregivers South San Francisco, CA
Companionship Services

Companionship Services

Using this kind of care is a fantastic way to make life easier for you or your senior loved one. At Always Best Care, our talented caregivers often fill the role of a companion for seniors. That way, older adults can enjoy their favorite local activities, such as visiting Alta Loma Park with friends while also receiving the care they need daily or weekly.

Common companionship services include:

  • Grocery Shopping
  • Transportation to Appointments
  • Nutritional Assistance
  • Conversation
  • Planning Outings
  • Completing Errands
  • Transportation to Community
  • Events and Social Outings
Home Care South San Francisco, CA
Respite Care

Respite Care Services

According to AARP, more than 53 million adults living in the U.S. provide care to someone over 50 years old. Unfortunately, these caregivers experience stress, exhaustion, and even depression. Our respite care services help family caregivers address urgent obligations, spend time with their children, and enjoy nearby activities. Perhaps more importantly, respite care gives family members time to recharge and regroup. Taking personal time to de-stress reduces the risk of caregiver burnout. So, if you've always wanted to eat at the local Lazy Bear or visit South San Francisco American Revolution bicentennial Observation committee capsule, don't feel bad. Doing so is great for both you and your loved one.

At the end of the day, our goal is to become a valuable part of your senior's daily routine. That way, we may help give them the highest quality of life possible. We know that staying at home is important for your loved one, and we are here to help make sure that is possible.

If you have been on the fence about non-medical home care, there has never been a better time than now to give your senior the care, assistance, and companionship they deserve.

 In-Home Care South San Francisco, CA

Benefits of Home Care in South San Francisco, CA

Always Best Care in-home services are for older adults who prefer to stay at home but need ongoing care that friends and family cannot provide. In-home care is a safe, effective way for seniors to age gracefully in a familiar place and live independent, non-institutionalized lives. The benefits of non-medical home care are numerous. Here are just a few reasons to consider senior care services from Always Best Care:

Always Best Care offers a full array of care options for patients at all levels of health. With our trusted elderly care services, your loved one will receive the level of care necessary for them to enjoy the highest possible quality of life.

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Aging in Place: The Preferred Choice for Most Seniors

While it's true that some seniors have complicated medical needs that prevent them from staying at home, aging in place is often the best arrangement for seniors and their families. With a trusted caregiver, seniors have the opportunity to live with a sense of dignity and do so as they see fit - something that is unavailable to many older people today.

In-home care makes it possible for millions of seniors to age in place every year. Rather than moving to a strange nursing home, seniors have the chance to stay at home where they feel the happiest and most comfortable.

Here are just a few of the reasons why older men and women prefer to age at home:

How much does a senior's home truly mean to them?

A study published by the American Society on Aging found that more than half of seniors say their home's emotional value means more than how much their home is worth in monetary value. It stands to reason, then, that a senior's home is where they want to grow old.

With the help of elderly care in South San Francisco, CA, seniors don't have to age in a sterilized care facility. Instead, they can age gracefully in the place they want to be most: their home. In contrast, seniors who move to a long-term care facility must adapt to new environments, new people, and new systems that the facility implements. At this stage in life, this kind of drastic change can be more harmful than helpful.

Institutional care facilities like nursing homes often put large groups of people together to live in one location. On any given day, dozens of staff members and caregivers run in and out of these facilities. Being around so many new people in a relatively small living environment can be dangerous for a seniors' health and wellbeing. When you consider that thousands of seniors passed away in nursing homes during the COVID-19 pandemic, opting for in-home care is often a safer, healthier choice for seniors.

Aging in place has been shown to improve seniors' quality of life, which helps boost physical health and also helps insulate them from viral and bacterial risks found in elderly living facilities.

For many seniors, the ability to live independently with assistance from a caregiver is a priceless option. With in-home care, seniors experience a higher level of independence and freedom - much more so than in other settings like a nursing home. When a senior has the chance to age in place, they get to live life on their own terms, inside the house that they helped make into a home. More independence means more control over their personal lives, too, which leads to increased levels of fulfillment, happiness, and personal gratification. Over time, these positive feelings can manifest into a healthier, longer life.

More independence, a healthier life, and increased comfort are only a few benefits of aging in place. You have to take into consideration the role of cost and convenience. Simply put, it's usually easier and more affordable to help seniors age in place than it is to move them into an institutional care facility. According to the US Department of Housing and Urban Development, seniors who age in the comfort of their homes can save thousands of dollars per month.

In-home care services from Always Best Care, for instance, are often less expensive than long-term solutions, which can cost upwards of six figures per year. To make matters worse, many residential care facilities are reluctant to accept long-term care insurance and other types of payment assistance.

With Always Best Care's home care services, seniors and their families have a greater level of control over their care plans. In-home care gives seniors the chance to form a bond with a trusted caregiver and also receive unmatched care that is catered to their needs. In long-term care facilities, seniors and their loved ones have much less control over their care plan and have less of a say in who provides their care.

 Elderly Care South San Francisco, CA

Affordable Care

In-home care is a valuable resource that empowers seniors to age in place on their own terms. However, a big concern for many families and their loved ones is how much in-home care costs. If you're worried that in-home care is too expensive, you may be pleasantly surprised to learn that it is one of the most affordable senior care arrangements available.

Typically, hiring an Always Best Care in-home caregiver for a few hours a week is more affordable than sending your loved one to a long-term care facility. This is true even for seniors with more complex care needs.

At Always Best Care, we will work closely with you and your family to develop a Care Plan that not only meets your care needs, but your budget requirements, too. Once we discover the level of care that you or your senior need, we develop an in-home care plan that you can afford.

In addition to our flexible care options, families should also consider the following resources to help offset potential home care costs:

If your loved one qualifies, Medicaid may help reduce in-home care costs. Review your CA's Medicaid program laws and benefits, and make sure your senior's financial and medical needs meet Medicaid eligibility requirements.
Attendance and aid benefits through military service can cover a portion of the costs associated with in-home care for veterans and their spouses.
Many senior care services like in-home care are included in long-term care insurance options. Research different long-term care solutions to find a plan that provides coverage for senior care.
Home care can be included as part of a senior's private insurance plan. Read over your loved one's insurance policy carefully or speak with their insurance provider to determine if in-home care is covered.
Depending on the life insurance plan, you may be able to apply your policy toward long-term care. You may be able to use long-term-care coverage to help pay for in-home elderly care.
 Senior Care South San Francisco, CA

Compassionate Care. Trusted Caregivers.

When you or your senior loved one needs assistance managing daily tasks at home, finding a qualified caregiver can be challenging. It takes a special kind of person to provide reliable care for your senior loved one. However, a caregiver's role involves more than meal preparation and medication reminders. Many seniors rely on their caregivers for companionship, too.

Our companion care services give seniors the chance to socialize in a safe environment and engage in activities at home. These important efforts boost morale and provide much-needed relief from repetitive daily routines. A one-on-one, engaging conversation can sharpen seniors' minds and give them something in which to be excited.

At Always Best Care, we only hire care providers that we would trust to care for our own loved ones. Our senior caregivers in South San Francisco, CA understand how important it is to listen and communicate with their seniors. A seemingly small interaction, like a short hug goodbye, can make a major difference in a senior's day. Instead of battling against feelings of isolation, seniors begin to look forward to seeing their caregiver each week.

Understanding the nuances of senior care is just one of the reasons why our care providers are so great at their job.

Unlike some senior care companies, our caregivers must undergo extensive training before they work for Always Best Care. In addition, our caregivers receive ongoing training throughout the year. This training ensures that their standard of care matches up to the high standards we've come to expect. During this training, they will brush up on their communication skills, safety awareness, and symptom spotting. That way, your loved one receives the highest level of non-medical home care from day one.

Assisted Living Referral Services

While it's true that many seniors prefer to age at home, sometimes in-home care isn't the best fit. For those seniors and their families, choosing an assisted living facility makes more sense. Unfortunately, finding the optimal care facility is easier said than done in today's day and age. That's when Always Best Care's assisted living referral services begin to make a lot of sense.

Assisted living is a form of housing intended for seniors who require varying degrees of medical and personal attention. Accommodations may include single rooms, apartments, or shared living arrangements. Assisted living communities are typically designed to resemble a home-like environment and are physically constructed to encourage the independence of residents.


Respite Care South San Francisco, CA

At assisted living communities, seniors receive help with daily activities such as bathing, dressing, and eating. They may also benefit from coordination of services with outside healthcare providers, and monitoring of resident activities to ensure their health, safety, and well-being. Caregivers who work at assisted living communities can also provide medication administration and personal care services for older adults.

Other services offered within assisted living communities can include some or all of the following:

  • Housekeeping
  • Laundry
  • Recreational Activities
  • Social Outings
  • Emergency Medical Response
  • Medication Monitoring
  • Family Visitation
  • Personal Care
 Caregivers South San Francisco, CA

At Always Best Care, our representatives can match your senior's emotional, physical, and financial needs with viable assisted living communities nearby. Results are based on comparative data, so you can select the best choice for you or your loved one.

Always Best Care works closely with local senior living communities to gain valuable knowledge that we then use to help seniors and their loved ones make informed decisions. This information can include basic care and rent, resident availability, and services provided. Because Always Best Care is compensated by these communities, we provide senior living referral services at no extra cost to you.

Some of the most popular assisted living communities to consider in our area include the following:

  • Westborough Royale
  • Aegis Living San Francisco
  • Rose Amor Care Home
  • Bougainvilleas Care Home
  • Care Home By RNs South San Francisco
  • Peninsula Del Rey
Home Care South San Francisco, CA

For many seniors, moving into a senior living community revolves around how and when they want to make a transition to more involved care. Some seniors are more proactive about transitioning to independent living. Others choose to remain home until their care needs or other requirements are satisfied. Remember - our staff is here to help. Contact our office today to learn more about assisted living communities and how we can find a facility that exceeds your expectations.

 In-Home Care South San Francisco, CA

Taking the First Step with Always Best Care

The first step in getting quality in-home care starts with a personal consultation with an experienced Always Best Care Care Coordinator. This initial consultation is crucial for our team to learn more about you or your elderly loved one to discover the level of care required. Topics of this consultation typically include:

A discussion of your needs and how our trained caregivers can offer assistance in the most effective way

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A draft of your care plan, which includes highly detailed notes and a framework for the care that you or your senior will receive

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Discuss payment options and help coordinate billing with your insurance provider

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Our caregivers are trained to spot changes that clients exhibit, like mental and physical decline. As your trusted senior care company, we will constantly assess and update your Care Plan to meet any new emotional, intellectual, physical, and emotional needs.

If you have never considered in-home care before, we understand that you and your family may have concerns about your Care Plan and its Care Coordinator. To help give you peace of mind, know that every team member and caregiver must undergo comprehensive training before being assigned to a Care Plan.

At the end of the day, we only hire the best of the best at Always Best Care. Whether you need home care in South San Francisco, CA 24-hours a day or only need a respite for a couple of hours, we are here to serve you.

When you're ready, we encourage you to contact your local Always Best Care representative to set up a Care Consultation. Our Care Coordinators would be happy to meet with you in person to get to know you better, discuss your needs, and help put together a personalized Care Plan specific to your needs.

 Elderly Care South San Francisco, CA

Latest News in South San Francisco, CA

2 SMC Plumbing Companies Face 6-Figure Fines For Trench Collapse

SAN MATEO COUNTY, CA — Two plumbing companies in South San Francisco are facing potential fines of over $500,000 by state regulators for safety violations that resulted in a worker injured by a collapsed trench in August 2024.Smelly Mel's Plumbing and Sewer Rat Plumbing were cited for $529,640 by the California Division of Occupational Safety and Health (Cal/OSHA) for worksite conditions that inspectors said the companies knew were unsafe. The companies can appeal within 15 days.Inspectors found eight violations for each ...

SAN MATEO COUNTY, CA — Two plumbing companies in South San Francisco are facing potential fines of over $500,000 by state regulators for safety violations that resulted in a worker injured by a collapsed trench in August 2024.

Smelly Mel's Plumbing and Sewer Rat Plumbing were cited for $529,640 by the California Division of Occupational Safety and Health (Cal/OSHA) for worksite conditions that inspectors said the companies knew were unsafe. The companies can appeal within 15 days.

Inspectors found eight violations for each company, a total of 16, including "two willful, serious accident-related violations -- meaning the businesses were aware of the safety hazards, had prior warning, and still failed to take corrective action," according to a Cal/OSHA press release on Monday.

The two companies are registered as separate businesses entities, but they share a phone number and a registered business address at 300 Shaw Road in South San Francisco, according to state business records.

A message left Tuesday afternoon requesting comment was not returned by press time.

Find out what's happening in South San Franciscofor free with the latest updates from Patch.

The accident happened on Aug. 1, when the companies were installing a sewer line at a residence on West 41st Avenue in the city of San Mateo. A trench that was dug for the line collapsed, leaving a worker seriously injured and buried in debris. The worker was hospitalized afterward, according to Cal/OSHA.

Cal/OSHA Chief Debra Lee said trench collapses are one of the most serious dangers in construction work and employers need to take measures to prevent them.

"These citations serve as a reminder that businesses must prioritize worker safety, especially during high-risk operations to avoid tragic accidents," Lee said in a statement.

Among the violations found were that the employers failed to conduct a safety meeting at the site, did not inspect the trench daily and did not provide a ladder or any means of escape for someone in the trench, which was more than 9 feet deep.

Cal/OSHA inspectors also found the companies did not provide proper foot protection to workers, file permits for the work on time, or have protection measures in the trench, like sloping or other design features that could have prevented collapse.

Story by Thomas Hughes, Bay City News.

Copyright © 2025 Bay City News, Inc. All rights reserved. Republication, rebroadcast or redistribution without the express written consent of Bay City News, Inc. is prohibited. Bay City News is a 24/7 news service covering the greater Bay Area.

After 'Super Slow-Speed Chase,' Opossum Rescued From Bay Bridge

"The opossum continued westbound in its attempt to evade, even attempting to turn around and escape going the wrong way," the CHP said.Maggie Fusek, Patch StaffBAY AREA, CA — An opossum was not playing possum last week when it tried to cross the San Francisco/Oakland Bay Bridge, according to the California Highway Patrol.It happened Feb. 24,...

"The opossum continued westbound in its attempt to evade, even attempting to turn around and escape going the wrong way," the CHP said.

Maggie Fusek, Patch Staff

BAY AREA, CA — An opossum was not playing possum last week when it tried to cross the San Francisco/Oakland Bay Bridge, according to the California Highway Patrol.

It happened Feb. 24, and a keen motorist spotted the marsupial trying to cross the upper deck of the Bay Bridge along the right shoulder. The driver quickly alerted CHP dispatch of the animal's crusade.

Personnel with CHP's San Francisco Area responded and found the critter approaching Treasure Island after making a lengthy journey up the incline portion of the bridge.

"As CHP San Francisco Motor Officer Pack located the opossum, an extremely slow-speed pursuit was initiated when the opossum failed to yield to Officer Pack's directions," the CHP said. "The opossum continued westbound in its attempt to evade, even attempting to turn around and escape going the wrong way against traffic. Officer Pack remained focused and kept a close eye on our furry friend while waiting for back-up units to assist with the safe capture of the fleeing perpetrator."

Julie Bainbridge, who runs an East Bay nonprofit animal rescue shelter, Jelly's Place, witnessed the super slow-speed pursuit and pulled over to lend a helping hand.

Find out what's happening in South San Franciscofor free with the latest updates from Patch.

"Our furry opossum friend was safely detained and removed from a dangerous location without further incident," the CHP said. "Special thanks to the alert 911 caller, as well as Julie B. for recognizing and assisting in rescuing this lost furry friend, whose true identity will remain undisclosed at this time."

The CHP said it does not condone stopping on a freeway or bridge to rescue an animal due to the dangers of speeding traffic and potentially distracted drivers.

"This was a unique and unusual situation where someone who was prepared and capable of assisting in this situation was able to help with the safe removal of the animal and will also provide it with potential medical care before its release."

Obesity Late-Comer AbbVie Inks Up to $2.2B Amylin Deal With Gubra

AbbVie is joining the amylin arena, though the pharma is still far behind leaders Novo Nordisk and Eli Lilly.AbbVie on Monday jumped into the hot weight-loss space, looking to gain ground on its Big Pharma peers, with a licensing deal with Danish company Gu...

AbbVie is joining the amylin arena, though the pharma is still far behind leaders Novo Nordisk and Eli Lilly.

AbbVie on Monday jumped into the hot weight-loss space, looking to gain ground on its Big Pharma peers, with a licensing deal with Danish company Gubra that aims to bring a long-acting amylin drug to the market.

Under the terms of the deal, AbbVie will front $350 million and put up to $1.875 billion on the line for development, commercial and sales milestones. Gubra, a service provider for pre-clinical research and peptide-based drug discovery, will be eligible to receive tiered royalties on global net sales of GUB014295, the asset at the center of Monday’s partnership.

Designed to be administered via an injection under the skin, GUB014295 is a long-acting analog of the amylin hormone, which acts on corresponding receptors to elicit feelings of satiety and suppress appetite, in turn lowering the overall intake of food. Amylin agonists such as GUB014295 also exert an inhibitory effect on the gastrointestinal system, helping to slow the emptying of the stomach, according to AbbVie’s press announcement.

The current obesity landscape is dominated by GLP-1 medicines like Novo Nordisk’s semaglutide brands Ozempic and Wegovy and Eli Lilly’s tirzepatide franchise of Mounjaro and Zepbound. But recently, more and more companies have been looking to amylin agents as an alternative weight-loss treatment.

According to a December 2024 note from Leerink Partners, which called amylin the “hottest new mechanism for obesity,” targeting this pathway could potentially improve the quality of weight loss, with greater reductions in fat instead of lean muscle. Amylin agonists could also be safer and more tolerable than GLP-1 drugs, the analysts said.

At the forefront of the amylin push is Novo, which is advancing CagriSema, a combo regimen of its semaglutide, with the long-acting amylin drug cagrilintide. Late last year, however, the pharma unveiled Phase III data for CagriSema, baring an efficacy estimate that fell below its own prior projections and sending its shares crashing 20%. The readout wiped some $72 billion off Novo’s market cap.

Fellow obesity leader Eli Lilly is also working on its own set of amylin programs, of which the mid-stage eloralintide is closest to the market. The pharma is testing a combination of the amylin drug eloralintide with tirzepatide in participants with obesity but without diabetes, for which data is expected in mid-2025. Eloralintide is also being assessed in patients with obesity and overweight with type 2 diabetes.

Several other biopharma players are advancing their own amylin hopefuls, including Zealand Pharma and AstraZeneca.

California weather: Storm to bring rain from S.F. to L.A. this week

Updated forecast: Here’s when rain is coming to the Bay AreaMarch is shaping up to be an active month of weather in California, with a moderate storm this week likely to precede several potent rain an...

Updated forecast: Here’s when rain is coming to the Bay Area

March is shaping up to be an active month of weather in California, with a moderate storm this week likely to precede several potent rain and snowmakers next week.

A system that dropped snow in the Sierra Nevada and sparked thunderstorms in the Central Valley on Sunday is on its way eastward, leaving the state mainly dry Monday. On Tuesday morning, a fizzling front could bring light rain to Northern California, primarily north of San Francisco.

The main storm of the week will arrive Wednesday and continue Thursday.

Wednesday’s storm is expected to target Central and Southern California, with up to an inch of rain in San Diego and Los Angeles. Bay Area rainfall amounts should remain below a quarter of an inch as most of the system’s moisture will stay south of the area.

Significant snowfall is expected from the storm. Mammoth Mountain and higher elevations of Yosemite National Park could pick up 1 to 2 feet of snow by Friday morning. Tahoe ski resorts are in line for about a half-foot of snow, but forecast totals could change slightly by Wednesday.

In addition to the precipitation, the storm is poised to bring a renewed episode of rough seas. Breaking waves of 20 to 25 feet are possible along west- and northwest-facing beaches. Multiple water rescues caused by large waves forced a temporary closure of Capitola Beach in Santa Cruz County on Saturday.

Dry weather will return Friday and continue Saturday, with temperatures returning to the 60s in the Bay Area. All signs point to adverse weather ramping up Sunday and continuing through mid-March, with several storms expected to hit California.

Monday breakdown

San Francisco: It will be a chilly, breezy day in the city. A cool westerly wind gusting 15 to 25 mph should keep temperatures a few degrees below average, in the mid-50s. There will be plenty of sunshine, but a few lingering low clouds over the hills. High clouds will increase around sunset. Overnight lows will be in the upper 40s.

North Bay: Patchy morning fog in the valleys will clear for a mix of sun and clouds the rest of the day. Highs are expected to reach the upper 50s in Napa, Petaluma and San Rafael and the low 60s in Santa Rosa, Vallejo, Fairfield and Vacaville. Wind will consistently gusts 15 to 20 mph, occasionally stronger. The wind will subside overnight, but high clouds will increase with lows in the low to mid-40s.

East Bay: Mainly sunny skies are expected in the morning. Puffy cumulus clouds may form over the hills midday but clouds will increase swiftly in the late afternoon and evening ahead of a weak disturbance expected to arrive Tuesday. Highs will be in the mid- to upper 50s in Richmond, Berkeley, Oakland, Hayward and Fremont. The inland valleys will be close to 60. It will be breezy near the water and in the passes, with gusts up to 25 mph. Lows will be in the mid-40s inland and upper 40s near the bay shoreline.

Pacific Coast and Peninsula: Partly to mostly sunny skies are expected along the Peninsula. Highs will be on the cool side, in the low to mid-50s in Daly City, Pacifica and Half Moon Bay and the mid- to upper 50s in South San Francisco, San Bruno, San Mateo and Redwood City. West-northwest winds could occasionally gust up to 30 mph in the San Bruno Gap. Clouds will increase in the evening, with lows in the upper 40s.

South Bay and Santa Cruz: A stray morning shower cannot be ruled out in the hills and mountains. Otherwise, Monday will be dry with a mix of sun and puffy cumulus clouds over the hills. Highs will be in the upper 50s to low 60s in San Jose, Mountain View, Milpitas and Santa Cruz. A cool air mass will keep temperatures in the low to mid-50s in the Santa Cruz Mountains. Overnight lows will fall to the low to mid-40s with increasing clouds.

Reach Anthony Edwards: [email protected]; Threads: @edwardsanthonyb; Bluesky: @edwardsanthonyb.bsky.social

March 3, 2025

Newsroom Meteorologist

Anthony Edwards is a newsroom meteorologist at The San Francisco Chronicle.

He joins the Chronicle from the University of Washington where he was previously the president of the campus weather forecasting team and an editor at the student newspaper, The Daily UW.

Edwards enjoys exploring San Francisco's parks, playing tennis, hiking, swimming and attending a ballgame when the Mariners visit the Giants and the Athletics.

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